Last season, Helio Castroneves joined the exclusive club of four-time winners, and now sits next to such as AJ Voight, Rick Mears and Al Ansera as the most successful riders involved in Brickyard.
Many will try to prevent him from winning his fifth victory this year, including reigning IndyCar champion Alex Palu and teammate Chip Ganassi on Racing Scott Dixon.
Two-time Indy 500 winner and former Formula 1 driver Takuma Sato is looking forward to qualifying this weekend and to the race itself in 10 days.
He is joined in the latest Autosport podcast by Charles Bradley and David Mulsher-Lopez of Motorsport.com with Martin Lee as host.
You can listen to the podcast using the player below or through all the good audio platforms including Spotify, Apple Podcasts and Google Podcasts.